Preclinical Phase

Oragenics Inc (NYSE: OGEN) has initiated a hamster challenge study to evaluate the immunogenicity and viral load reduction impact of its COVID-19 vaccine candidate. Related Content: Oragenics's New Preclinical Data Supports Its Approach For COVID-19 Vaccine Development. The...

NanoViricides Inc (NYSE: NNVC) has in-licensed oral antiviral candidates targeting COVID-19 and variants from TheraCour Pharma Inc. The Company executed a license agreement on September 8. Under the Agreement, the discovery of ligands and polymer materials, formulations, chemistry & chemical...

PolyPid Ltd (NASDAQ: PYPD) has announced preclinical data in two key Glioblastoma Multiform (GBM) animal models of its OncoPLEX intra-tumoral cancer therapy program. OncoPLEX is designed to provide controlled local exposure to docetaxel, one of the most widely used chemotherapy...

Tonix Pharmaceuticals Holding Corp (NASDAQ: TNXP) announced that it received the official written response from a Type B pre-Investigational New Drug (IND) meeting with the FDA for its COVID-19 vaccine candidate. Based on the response, the Company expects to begin a Phase 1 study in...

Lexaria Bioscience Corp (NASDAQ: LEXX) has formally begun the process towards an Investigational New Drug (IND) application filing with the FDA for its DehydraTECH-processed cannabidiol (DehydraTECH-CBD) as a prospective pharmaceutical treatment for hypertension. Lexaria has...

Wedbush initiated coverage of Tango Therapeutics Inc (NASDAQ: TNGX) with an Outperform rating and a $12 price target.  Analyst Robert Driscoll believes Tango's unique synthetic lethality approach is differentiated.  Furthermore, he expects Tango to leverage this...

Immunome Inc's (NASDAQ: IMNM) three-antibody cocktail (IMM-BCP-01) has demonstrated potent neutralizing activity against SARS-CoV-2 Lambda (C.37) and Delta AY.1/2 (Delta Plus) variants in preclinical testing.  Related Content: Immunome's COVID-19 Antibody Shows Neutralizing...

Celsion Corporation (NASDAQ: CLSN) has announced results from preclinical in vivo studies of its next-generation PLACCINE DNA vaccine platform. Data showed that the vaccine candidate produced antibodies and cytotoxic T-cell response specific to the spike antigen of SARS-CoV-2 in...

​​​​​Sonnet BioTherapeutics Holdings Inc (NASDAQ: SONN) stock is soaring during premarket in reaction to the selection of SON-1410 as a development candidate for melanoma and renal cancers. SON-1410 represents Sonnet's second bispecific compound integrating Interleukin 12 (IL-12...

Oragenics Inc's (NYSE: OGEN) stabilized pre-fusion spike protein trimer generates neutralizing antibodies in mice after immunization against SARS-CoV-2 when administered with several intramuscular (IM) and intranasal (IN) adjuvants.  The expression platform is developed by...

Privately held company Polyrizon Ltd, in which Medigus Ltd (NASDAQ: MDGS) owns 35.86% of share capital, has announced preclinical data for its Capture and Contain (C&C) platform technology. Related Content: Medigus-Backed Polyrizon's COVID-19 Technology...

Sorrento Therapeutics Inc (NASDAQ: SRNE) has announced preclinical results for its mRNA-based COVID-19 vaccine against SARS-CoV-2. STI-mRNA includes a proprietary designer Spike-encoding mRNAs to elicit cellular and humoral immunity against the early virus strain and emerging variants of concern...

RedHill Biopharma Ltd (NASDAQ: RDHL) has announced preliminary results of a new preclinical study for its COVID-19 treatment candidate, opaganib. Related: RedHill's Novel Late-Stage Pills Hold Promise Against COVID-19 and its Variants Data showed potent inhibition by...

iBio Inc (NYSE: IBIO) has signed an exclusive license agreement with RubrYc Therapeutics Inc for RTX-003, an immunotherapy candidate targeting regulatory T cells (Tregs).  Related: IBio Adds Three Cancer Antibody Programs. iBio plans to use its development and...

The FDA has issued a clinical hold on PolarityTE Inc's (NASDAQ: PTE) SkinTE Investigational New Drug Application (IND) for chronic cutaneous ulcers. The FDA provided feedback on certain Chemistry, Manufacturing, and Control (CMC) items that need to be addressed before...